cytolethal distending toxin B (CdtB) and antivinculin antibodies
المؤلف:
Kathleen Deska Pagana, Timothy J. Pagana, Theresa Noel Pagana.
المصدر:
Mosbys diagnostic and laboratory test reference
الجزء والصفحة:
15th edition , p322
2025-12-04
65
Type of test Blood
Normal findings
1-2.5 titers
Test explanation and related physiology
With no clear pathophysiology, irritable bowel syndrome (IBS) is currently identified through a diagnosis of exclusion and is considered a functional disease. The Rome IV criteria are used to diagnose IBS. These criteria include the following: symptoms of recurrent abdominal pain or discomfort with a marked change in bowel habit for at least 6 months, symptoms on at least 3 days for at least 3 months, and two or more of the following pain descriptions:
• Pain relieved by a bowel movement
• Pain onset linked to a change in frequency of stool
• Pain onset linked to a change in appearance of stool
Patients undergo extensive testing to rule out inflammatory bowel disease (IBD), and maldigestion (such as celiac disease). Diarrhea-predominant irritable bowel syndrome (D-IBS) can be precipitated by acute gastroenteritis. Anti-CdtB and antivinculin antibodies may occur after an acute bout of gastroenteritis. Persistent elevation of these antibodies is predictive of D-IBS rather than IBD or celiac disease.
Procedure and patient care
• See inside front cover for Routine Blood Testing.
• Fasting: no
• Blood tube commonly used: A central laboratory testing kit
• Obtain a list of foods ingested in the last 48 hours.
• Assess severity of symptoms and the hydrational status of the patient with diarrhea.
Abnormal findings
- Diarrhea-predominate irritable bowel syndrome
- Acute gastroenteritis
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