Yellow fever causes a wide range of symptoms varying from no symptoms to mild febrile illness to severe disease with multiorgan involvement with a high fatality rate.

Incubation period of YF is 3–6 days from the day of mosquito inoculation to development of symptoms with a median of 4 days. Clinical manifestations of YF has been classically divided into three different phases, namely; infection, remission and intoxication (Fig. 1).

Fig1. Time course of yellow fever virus infection

Period of infection: This includes the onset of symptoms which is typically abrupt and presents with fever, headache, malaise, vomiting. This period corresponds with peak viremia during which YFV can be detected in blood by virus isolation or molecular methods. During this period, the person is infectious to mosquitoes. It lasts for about 3–6 days. Majority of the infected persons recover within one week of initial illness.

Period of remission: Some patients may experience a short period of remission following the infection phase with resolution of fever and improvement in symptoms and signs. Most of the patients recover during this phase.

Period of intoxication: A subset of 15% YFV infected patients develop severe form of disease called phase of intoxication. This phase is marked by return of fever with severe epigastric pain, nausea, vomiting, jaundice (causing yellow skin from which the name yellow fever is given). Hepatic dysfunction, renal failure and bleeding diathesis leading to the manifestations of hemorrhagic fever are the prominent clinical features of severe YF disease. Hemorrhagic manifestations occur due to consumptive coagulopathy and reduce production of clotting factors. Hepatorenal failure along with circulatory collapse leads to metabolic disturbances, coma and death. About 20–50% of patients who enters the period of intoxication die within 7–10 days.

This phase is characterized by absence of viremia and detectable anti-YF antibodies.

اخر الاخبار

اخبار العتبة العباسية المقدسة

قسم التطوير يقيم دورة عن أخلاقيات المهنة للمنتسبين الجدد

تتضمن زيارة المراقد المقدسة في كربلاء.. معهد القرآن الكريم النسوي ينظم سفرة دينية لطالباته

المجمع العلمي يحتفي بذكرى ولادة الإمامين الباقر والهادي (عليهما السلام)

قسم الشؤون الفكرية يطلق فعاليات الأسبوع الثالث من برنامج البذرة الصالحة

المزيد

الآخبار الصحية

ثورة طبية.. الذكاء الاصطناعي يكشف سرطان الكلى في وقت قياسي

لتعزيز الطاقة والتغلب على التعب.. عليك بـ7 طرق بسيطة

لتحسين الهضم والتحكم في الشهية.. ما أفضل وقت لتناول التمر؟

خبراء يكشفون تأثير الاستحمام في الظلام على جودة النوم !

المزيد

الآخبار التكنلوجية

إزالة ثاني أكسيد الكربون من الغلاف الجوي.. ما دور المحيطات والبحار؟

نظائر الهيليوم مقياس لاكتشاف رواسب الذهب.. كيف ذلك؟

الصين تطلق أول ناقلة نفط خام ذكية في العالم تعمل بالميثانول

الزمن على المريخ أسرع من الأرض.. دراسة علمية تكشف الفوارق

المزيد

مواضيع ذات صلة

Structure and Function of Hemagglutinin

Structure and Composition of influenza viruses

Filoviruses Diseases

Pathogenesis of SARS-CoV-2 and COVID-19

Viral Serology :General Principles

Virus detection methods: Cell Culture

Virus detection methods: Molecular Detection Using Nucleic Acid Probes and Polymerase Chain Reaction Assays

Virus detection methods: Immunodiagnosis (Antigen Detection)

Arenavirus diseases

Bunyavirus diseases

Bunyavirus Encephalitis viruses

Dengue Virus