Drug analysis , Immunological methods
المؤلف:
Sue Jickells , Adam Negrusz (Editors)
المصدر:
Clarkes Analytical Forensic Toxicology
الجزء والصفحة:
158
2026-10-05
143
Drug analysis
Immunological methods
Immunoassays are used as screening tests because of their sensitivity, speed and convenience. The procedure must be compatible with the screening test used (i.e. detergents or hair digestion products must not interfere with the assay). Neutralisation, in case of chemical hydrolysis, is always necessary. The destruction of the organic protein matrix of hair must be done under conditions sufficiently mild not to damage the entrapped analyte or the protein antibodies subsequently added for the immunoassay. Quantification by immunoassay is difficult to achieve, as the specificity of most kits is directed to a group of drugs and drug metabolites rather than to a single substance.
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