تسجيل الدخول

تسجيل

Drug identification , Cocaine

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  160

2026-10-05

134

Drug identification

Cocaine

Procedures for the detection of cocaine have been published in several papers (Moeller 1992; Sachs and Kintz 1998). There is considerable variety in the work-up and derivatisation conditions. In most cases, cocaine is found in higher concentrations than benzoylecgonine and methyl ecgonine (Henderson et al. 1992; Moeller et al. 1992a; Kidwell 1993). The determination of the pyrolysis product of cocaine, anhydroecgonine methylester (AEME), helps to distinguish cocaine users from crack users. Kintz et al. (1995a) found AEME in the range 0.2–2.4 ng/mg for seven crack users. An important study with controlled doses of cocaine-d5 was published in 1996 (Henderson et al. 1996). The deuterium labelled cocaine was administered intravenously and/or intranasally in doses of 0.6–4.2 mg/kg under controlled conditions. A single dose could be detected for 2–6 months, and the minimum detectable dose appeared to be between 22 and 35 mg.