تسجيل الدخول

تسجيل

Drug identification , Amfetamines

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  160

2026-10-05

148

Drug identification

Amfetamines

Articles that deal with amfetamine and methamfetamine have been published (Nakahara et al. 1990). The work-up (liquid–liquid extraction after acid or alkaline hydrolysis) and derivatisation procedures (trifluoroacetic anhydride (TFA)) are similar in most of the publications. After methamfetamine intake, its major metabolite, amfetamine, can be detected in hair samples, and the differentiation between methamfet amine and amfetamine intake is shown by the ratio between the drugs. In 1992, methylene dioxy-N-methamfetamine (MDMA or ecstasy) was first detected in the hair of an abuser at the concentration of 0.6 ng/mg (Moeller et al. 1992b). In Europe, MDMA is one of the most frequently identified amfetamines, reflecting the fact that this drug is more widely abused in Europe than amfetamine or methamfetamine. Since the first screening procedure in 1995, other methods have been published (Kintz et al. 1995b; Kikura et al. 1997; Rothe et al. 1997). These procedures permit the determination of amfetamine, methamfetamine, methylene dioxyamfetamine, methylenedioxymethamfeta mine, methylenedioxyethamfetamine and N-methylbenzodioxazolylbutanamine (MBDB) by electron impact GC-MS.