تسجيل الدخول

تسجيل

Drug identification , Cannabis

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  P160-161

2026-10-05

156

Drug identification

Cannabis

In 1995 the first results for cannabis in hair using GC-MS and the determination in the same run of D9-tetrahydrocannabinol (THC) and its major metabolite 11-nor-D9-THC carboxylic acid (THC COOH) were reported (Cirimele et al. 1995b; Jurado et al. 1995). The measured concentrations were low, particularly in comparison with other drugs. Some authors suggested the use of negative chemical ionisation (Kintz et al. 1995c) to target the drugs or the application of tandem MS (Uhl 1997). More recently, a simpler method was proposed (Cirimele et al. 1996a) based on the simultaneous identification of cannabinol (CBN), cannabidiol (CBD) and THC. This procedure is a screening method that is rapid, economical, and does not require derivatisation prior to analysis. To avoid potential external contamination (because THC, CBD and CBN are present in smoke), the endogenous metabolite THC-COOH should be sought to confirm drug use. The concentrations measured are very low, particularly for THC-COOH (pg/mg range).