تسجيل الدخول

تسجيل

Oocyte– Granulosa cell Interaction : Novel Pathways of Follicle Activation

المؤلف:  Wass, J. A. H., Arlt, W., & Semple, R. K. (Eds.).

المصدر:  Oxford Textbook of Endocrinology and Diabetes

الجزء والصفحة:  3rd edition , p1261-1262

2026-10-26

215

One of the novel discovered pathways in the process of folliculo genesis appears to be ‘Hippo signalling’ that is also essential for organ size control. As an incision is made to the ovary, G- actin within granulosa cells polymerize to F- actin and inhibits several negative growth regulators acting in a serine/ threonine kinase cascade that ultimately phosphorylates and inactivates key transcriptional coactivators, Yes- associated protein and transcriptional co- activator with PDZ- binding motif. These alterations induce expression of downstream CCN growth factors and BIRC apoptosis inhibitors that in turn activates dormant follicles.

 Another molecular mechanism to induce dormant follicles ap pears to be related with ‘PTEN- PI3K- AKT pathway’. Stimulation of phosphatidylinositol- 3- kinase (PI3K) yields AKT stimulation that subsequently suppresses FOXO3 actions in nucleus to promote primordial follicle growth. Meanwhile, PTEN gene encodes an enzyme that converts PIP3 to PIP2, thus damping the actions of PI3K. Oocyte- specific deletion of the PTEN gene leads to global activation of primordial follicles whereas treatment with PTEN inhibitors promotes primordial follicle activation.