Biological Reduction of Aldehydes and Ketones

Addition to a carbonyl by a semi-anionic hydride, such as NaBH₄, results in conversion of the carbonyl compound to an alcohol. The hydride from the BH₄^- anion acts as a nucleophile, adding H^- to the carbonyl carbon. A proton source can then protonate the oxygen of the resulting alkoxide ion, forming an alcohol.

Formally, that process is referred to as a reduction. Reduction generally means a reaction in which electrons are added to a compound; the compound that gains electrons is said to be reduced. Because hydride can be thought of as a proton plus two electrons, we can think of conversion of a ketone or an aldehyde to an alcohol as a two-electron reduction. An aldehyde plus two electrons and two protons becomes an alcohol.

Aldehydes, ketones and alcohols are very common features in biological molecules. Converting between these compounds is a frequent event in many biological pathways. However, semi-anionic compounds like sodium borohydride don't exist in the cell. Instead, a number of biological hydride donors play a similar role.

NADH is a common biological reducing agent. NADH is an acronym for nicotinamide adenine dinucleotide hydride. Insetad of an anionic donor that provides a hydride to a carbonyl, NADH is actually a neutral donor. It supplies a hydride to the carbonyl under very specific circumstances. In doing so, it forms a cation, NAD⁺. However, NAD⁺ is stabilized by the fact that its nicotinamide ring is aromatic; it was not aromatic in NADH.

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مواضيع ذات صلة

Predominantly E alkenes can be formed by stereoselective elimination reactions

Addition of nucleophiles to alkynes

E-selective reduction of alkynes using sodium in liquid ammonia

Using light to make Z alkenes from E alkenes

Equilibration of alkenes

Exploiting cyclic compounds

Lewis acids promote couplings via oxonium ions

Allyl silanes are more reactive than vinyl silanes but also react through β-silyl cations

Allyl silanes as nucleophiles

Vinyl silanes offer a regio- and stereoselective route to alkenes

Aryl silanes undergo ipso substitution with electrophiles

Silicon stabilizes a positive charge on the β carbon