Previously, you learned to balance chemical equations by comparing the numbers of each type of atom in the reactants and products. The coefficients in front of the chemical formulas represent the numbers of molecules or formula units (depending on the type of substance). Here, we will extend the meaning of the coefficients in a chemical equation.

Consider the simple chemical equation

The convention for writing balanced chemical equations is to use the lowest whole-number ratio for the coefficients. However, the equation is balanced as long as the coefficients are in a 2:1:2 ratio. For example, this equation is also balanced if we write it as

The ratio of the coefficients is 4:2:4, which reduces to 2:1:2. The equation is also balanced if we were to write it as

because 22:11:22 also reduces to 2:1:2.

Suppose we want to use larger numbers. Consider the following coefficients:

These coefficients also have the ratio 2:1:2 (check it and see), so this equation is balanced. But 6.022 × 10²³ is 1 mol, while 12.044 × 10²³ is 2 mol (and the number is written that way to make this more obvious), so we can simplify this version of the equation by writing it as

We can leave out the word mol and not write the 1 coefficient (as is our habit), so the final form of the equation, still balanced, is

Now we interpret the coefficients as referring to molar amounts, not individual molecules. The lesson? Balanced chemical equations are balanced not only at the molecular level but also in terms of molar amounts of reactants and products. Thus, we can read this reaction as “two moles of hydrogen react with one mole of oxygen to produce two moles of water.”

By the same token, the ratios we constructed to describe molecules reaction can also be constructed in terms of moles rather than molecules. For the reaction in which hydrogen and oxygen combine to make water, for example, we can construct the following ratios:

We can use these ratios to determine what amount of a substance, in moles, will react with or produce a given number of moles of a different substance. The study of the numerical relationships between the reactants and the products in balanced chemical reactions is called stoichiometry.