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Date: 19-9-2018
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Date: 10-7-2018
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Date: 22-8-2019
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Several methods for reducing nitro groups to amines are known. These include catalytic hydrogenation (H2 + Pd/C), zinc or tin in dilute HCl, and sodium sulfide in ammonium hydroxide solution.
During this reaction the hydride nucleophile attacks the electrophilic carbon in the nitrile to form an imine anion. Once stabilized by a Lewis acid-base complexation the imine salt can accept a second hydride to form a dianion. The dianion can then be converted to an amine by addition of water.
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