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Date: 21-11-2019
1448
Date: 20-8-2019
1215
Date: 15-12-2016
1557
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Both ‘Grignard reagents’ and organolithiums are particularly useful in nucleophilic addition reactions with carbonyl electrophiles, such as ketones:
The nucleophilic carbon need not be primary as in the picture above. The synthesis of 2-phenyl-2-propanol, for example, can be carried by reacting phenylmagnesium bromide with acetone.
Addition to formaldehyde gives 1o alcohols