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Date: 10-7-2018
2116
Date: 1-12-2019
1108
Date: 29-5-2017
2003
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Earlier, we examined the aldol reactions as a nucleophilic carbonyl addition in section 20.6, in which the electrophile is the carbonyl carbon of an aldehyde or ketone. A nucleophilic enolate can also attack the carbonyl carbon of a carboxylic acid derivative in a nucleophilic acyl substitution reaction.
This is referred to as a Claisen condensation, after the German chemist Ludwig Claisen (1851-1930).
Basic reaction
Going from reactants to products simply
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